Monoamine neurotransmitters and mood swings: a dynamical systems approach

Autor: R. Loula, L. H. A. Monteiro
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: Mathematical Biosciences and Engineering, Vol 19, Iss 4, Pp 4075-4083 (2022)
Druh dokumentu: article
ISSN: 1551-0018
DOI: 10.3934/mbe.2022187?viewType=HTML
Popis: Serotonin, dopamine and norepinephrine are monoamine neurotransmitters that modulate our mood state. Hence, imbalances in the levels of these neurotransmitters have been linked to the incidence of several psychiatric disorders. Here, a mathematical model written in terms of ordinary differential equations is proposed to represent the interaction of these three neurotransmitters. It is analytically and numerically shown that this model can experience a Hopf bifurcation. Thus, by varying a parameter value, the neurotransmitter levels can change from a steady state to an oscillatory behavior, which may be at least a partial explanation of the mood swings observed in depressed people.
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