Performance analysis of AL amyloidosis cardiac biomarker staging systems with special focus on renal failure and atrial arrhythmia
| Autor: | Tobias Dittrich, Axel Benner, Christoph Kimmich, Fabian aus dem Siepen, Kaya Veelken, Arnt V. Kristen, Tilmann Bochtler, Hugo A. Katus, Carsten Müller-Tidow, Ute Hegenbart, Stefan O. Schönland |
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| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: | |
| Zdroj: | Haematologica, Vol 104, Iss 7 (2019) |
| Druh dokumentu: | article |
| ISSN: | 0390-6078 1592-8721 86004875 |
| DOI: | 10.3324/haematol.2018.205336 |
| Popis: | Systemic light chain amyloidosis is a rare and life-threatening disorder, for which accurate risk stratification is crucial. Current cardiac staging systems (MAYO2004, MAYO3b, and MAYO2012) are mainly based on biomarkers, which have uncertain reliability in the context of atrial fibrillation, arrhythmia or pacemaker stimulation as well as renal insufficiency. We compared the performance of the established staging systems with particular regard to these comorbidities in 1,224 patients with systemic light chain amyloidosis diagnosed at our center from July 2002 until March 2017. We first characterized the subsets with an estimated glomerular filtration rate |
| Databáze: | Directory of Open Access Journals |
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