A Follow-up Study on BMI-SDS and Insulin Resistance in Overweight and Obese Children at Risk for Type 2 Diabetes Mellitus
| Autor: | Soulmaz Fazeli Farsani PharmD, MSc, Marloes P. van der Aa MD, Catherijne A. J. Knibbe PharmD, PhD, Anthonius de Boer MD, PhD, Marja M. J. van der Vorst MD, PhD |
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| Jazyk: | angličtina |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Global Pediatric Health, Vol 2 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2333-794X 2333794X |
| DOI: | 10.1177/2333794X14568451 |
| Popis: | Objectives . To evaluate body mass index standard deviation score (BMI-SDS), insulin sensitivity, and progression to type 2 diabetes mellitus (T2DM) in children at risk for T2DM approximately 3 years after being diagnosed with overweight/obesity and insulin resistance (measured by Homeostasis Model Assessment of Insulin Resistance [HOMA-IR]). Methods . Out of 86 invited children, 44 (mean age 15.4 ± 3.6 years) participated. Medical history, physical examination, and laboratory workup were performed. Results . While the mean BMI-SDS significantly increased from 2.9 to 3.4, the mean HOMA-IR significantly decreased from 5.5 to 4.6 (baseline vs follow-up visit). Change in HOMA-IR was only due to a decrease in mean fasting plasma insulin (24.1 vs 21.1, P = .073). Conclusions . Although increase in BMI-SDS in these children is worrisome, the American Diabetes Association recommended screening interval of 3 years for children at risk for T2DM is not too long based on the fact that none of our study participants developed T2DM. |
| Databáze: | Directory of Open Access Journals |
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