Bora phosphorylation substitutes in trans for T-loop phosphorylation in Aurora A to promote mitotic entry

Autor:	N. Tavernier, Y. Thomas, S. Vigneron, P. Maisonneuve, S. Orlicky, P. Mader, S. G. Regmi, L. Van Hove, N. M. Levinson, G. Gasmi-Seabrook, N. Joly, M. Poteau, G. Velez-Aguilera, O. Gavet, A. Castro, M. Dasso, T. Lorca, F. Sicheri, L. Pintard
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	Science
Zdroj:	Nature Communications, Vol 12, Iss 1, Pp 1-22 (2021)
Druh dokumentu:	article
ISSN:	2041-1723
DOI:	10.1038/s41467-021-21922-w
Popis:	Tavernier et al. decipher the mechanism by which the intrinsically disordered protein Bora, phosphorylated by Cyclin-Cdk, potentiates AURKA activity towards Polo-like kinase 1. Furthermore, they demonstrate the importance of this mechanism for timely mitotic entry in Xenopus and human cells.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/c85f4e856295480db1bc7aa81205cfc6 Zobrazit plný text záznamu Full text from SpringerLink View record in DOAJ