| Autor: |
Cho Rim Kim, Yong Chan Cho, Seung Ho Lee, Jae Hoon Han, Min Ji Kim, Han Bi Ji, Se‐Na Kim, Chang Hee Min, Byung Ho Shin, Cheol Lee, Young Min Cho, Young Bin Choy |
| Jazyk: |
angličtina |
| Rok vydání: |
2023 |
| Předmět: |
|
| Zdroj: |
Bioengineering & Translational Medicine, Vol 8, Iss 1, Pp n/a-n/a (2023) |
| Druh dokumentu: |
article |
| ISSN: |
2380-6761 |
| DOI: |
10.1002/btm2.10320 |
| Popis: |
Abstract Self‐injectable therapy has several advantages in the treatment of metabolic disorders. However, frequent injections with needles impair patient compliance and medication adherence. Therefore, we develop a fully implantable device capable of on‐demand administration of self‐injection drugs via noninvasive manual button clicks on the outer skin. The device is designed to infuse the drug only at the moment of click actuation, which allows for an accurate and reproducible drug infusion, and also prevents unwanted drug leakage. Using a mechanical means of drug infusion, this implantable device does not contain any electronic compartments or batteries, making it compact, and semi‐permanent. When tested in animals, the device can achieve subcutaneous injection‐like pharmacokinetic and pharmacodynamic effects for self‐injection drugs such as exenatide, insulin, and glucagon. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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