ARNI Versus Perindopril for Remodeling in HFrEF. A Cohort Study

Autor: Noor Muhammad Azlan Shah Bin Atan MBBS, Mohd Firdaus Bin Hadi MBBS, Victoria Wen Yeng Teoh, Mahmoud Danaee PhD, Alexander Loch MBBS, MRCP, MCEM, MD
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Journal of Cardiovascular Pharmacology and Therapeutics, Vol 28 (2023)
Druh dokumentu: article
ISSN: 1940-4034
10742484
DOI: 10.1177/10742484231195019
Popis: Introduction: Ventricular remodeling is a mal-adaptive process. Both angiotensin-converting enzyme inhibitors and sacubitril/valsartan have been shown to reverse remodeling in mostly uncontrolled observational studies. There is a lack of head-to-head studies. Methods: This cohort study compares the remodeling effects of angiotensin receptor blockers combined with a neprilysin inhibitor (ARNI) and perindopril in heart failure with reduced ejection fraction (HFrEF) patients between January 2017 and December 2020. Inclusion criteria: (i) age > 18 years, (ii) recent diagnosis of de-novo HFrEF (EF
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