What Is the Impact of Multimodal Treatment in Patients with Leiomyosarcoma of Bone? A Multicenter Study of 35 Patients with an Ultra-Rare Tumor Entity

Autor:	Maya Niethard, Carolin Knebel, Andreas Leithner, Per-Ulf Tunn, Janosch Schoon, Peter Reichardt, Athanasios Pogkas, Joanna Szkandera, Daniel Pink, Dimosthenis Andreou
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	leiomyosarcoma of bone bone sarcoma systemic chemotherapy surgical treatment patient outcome rare primary malignant bone sarcoma (RPMBS) Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancers, Vol 16, Iss 9, p 1633 (2024)
Druh dokumentu:	article
ISSN:	2072-6694
DOI:	10.3390/cancers16091633
Popis:	Primary leiomyosarcoma of bone (LMSoB) is extremely rare, comprising only p = 0.0015). Axial tumor localization was associated with worse event-free survival (EFS) probability (p < 0.001) and OS (p = 0.0082). A high proportion of our patients developed secondary metastases. Furthermore, the perioperative chemotherapy protocols applied to our patients were not associated with an improved EFS or OS. Therefore, the benefit of perioperative chemotherapy in LMSoB needs to be further investigated, and the choice of agents still needs to be clarified.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/85dfb09fb45046efabdf12a911ab215e Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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