Fluorinated Human Serum Albumin as Potential 19F Magnetic Resonance Imaging Probe

Autor:	Dmitry E. Mitin, Alexey S. Chubarov
Jazyk:	angličtina
Rok vydání:	2023
Předmět:	human serum albumin N-homocysteinylation 19F-NMR magnetic resonance imaging probes fluorinated homocysteine thiolactone octafluorotoluene Organic chemistry QD241-441
Zdroj:	Molecules, Vol 28, Iss 4, p 1695 (2023)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules28041695
Popis:	Fluorinated human serum albumin conjugates were prepared and tested as potential metal-free probes for 19F magnetic resonance imaging (MRI). Each protein molecule was modified by several fluorine-containing compounds via the N-substituted natural acylating reagent homocysteine thiolactone. Albumin conjugates retain the protein’s physical and biological properties, such as its 3D dimensional structure, aggregation ability, good solubility, proteolysis efficiency, biocompatibility, and low cytotoxicity. A dual-labeled with cyanine 7 fluorescence dye and fluorine reporter group albumin were synthesized for simultaneous fluorescence imaging and 19F MRI. The preliminary in vitro studies show the prospects of albumin carriers for multimodal imaging.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/85df045109bb418eb46db945c1a77d63 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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