Distinct fate, dynamics and niches of renal macrophages of bone marrow or embryonic origins

Autor: Fengming Liu, Shen Dai, Dechun Feng, Zhongnan Qin, Xiao Peng, Siva S. V. P. Sakamuri, Mi Ren, Li Huang, Min Cheng, Kabir E. Mohammad, Ping Qu, Yong Chen, Chunling Zhao, Faliang Zhu, Shujian Liang, Bertal H. Aktas, Xiaofeng Yang, Hong Wang, Prasad V. G. Katakam, David W. Busija, Tracy Fischer, Prasun K. Datta, Jay Rappaport, Bin Gao, Xuebin Qin
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-020-16158-z
Popis: Renal macrophages (RMs) can be of bone marrow or embryonic origin, but their abundance, fate and metabolic profiles in physiological and pathogenic settings are still unclear. Here the authors show, by characterizing these two RMs in multiple transgenic mouse lines, that they exhibit distinct dynamics, homeostasis, immune activity, and metabolic properties.
Databáze: Directory of Open Access Journals