Edaravone Preserves Coronary Microvascular Endothelial Function After Ischemia/Reperfusion on the Beating Canine Heart In Vivo

Autor: Renan Sukmawan, Toyotaka Yada, Eiji Toyota, Yoji Neishi, Teruyoshi Kume, Yoshiro Shinozaki, Hidezo Mori, Yasuo Ogasawara, Fumihiko Kajiya, Kiyoshi Yoshida
Jazyk: angličtina
Rok vydání: 2007
Předmět:
Zdroj: Journal of Pharmacological Sciences, Vol 104, Iss 4, Pp 341-348 (2007)
Druh dokumentu: article
ISSN: 1347-8613
DOI: 10.1254/jphs.FP0070186
Popis: We examined whether edaravone (3-methyl-1-phenyl-2-pyrazolin-5-one), a free radical scavenger, exerts its protective effect on coronary microvessels after ischemia/reperfusion (I/R) in vivo. Ninety-minute coronary occlusion followed by reperfusion was performed in 16 open-chest dogs with and without edaravone administration. Coronary small artery (≥100 µm in size) and arteriolar (
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