Sub-centrosomal mapping identifies augmin-γTuRC as part of a centriole-stabilizing scaffold

Autor: Nina Schweizer, Laurence Haren, Ilaria Dutto, Ricardo Viais, Cristina Lacasa, Andreas Merdes, Jens Lüders
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-26252-5
Popis: The γ-tubulin ring complex (γTuRC) nucleates microtubules at the centrosome, but how this function is related to γTuRC subcentrosomal distribution is unclear. Here the authors show that γTuRC in the centriole lumen has a nucleation-independent role in centriole integrity and cilium assembly.
Databáze: Directory of Open Access Journals