| Autor: |
Colin Groot, Michel J. Grothe, Shubhabrata Mukherjee, Irina Jelistratova, Iris Jansen, Anna Catharina van Loenhoud, Shannon L. Risacher, Andrew J. Saykin, Christine L. Mac Donald, Jesse Mez, Emily H. Trittschuh, Gregor Gryglewski, Rupert Lanzenberger, Yolande A.L. Pijnenburg, Frederik Barkhof, Philip Scheltens, Wiesje M. van der Flier, Paul K. Crane, Rik Ossenkoppele |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
NeuroImage: Clinical, Vol 30, Iss , Pp 102660- (2021) |
| Druh dokumentu: |
article |
| ISSN: |
2213-1582 |
| DOI: |
10.1016/j.nicl.2021.102660 |
| Popis: |
The clinical presentation of Alzheimer’s disease (AD) varies widely across individuals but the neurobiological mechanisms underlying this heterogeneity are largely unknown. Here, we compared regional gray matter (GM) volumes and associated gene expression profiles between cognitively-defined subgroups of amyloid-β positive individuals clinically diagnosed with AD dementia (age: 66 ± 7, 47% male, MMSE: 21 ± 5). All participants underwent neuropsychological assessment with tests covering memory, executive-functioning, language and visuospatial-functioning domains. Subgroup classification was achieved using a psychometric framework that assesses which cognitive domain shows substantial relative impairment compared to the intra-individual average across domains, which yielded the following subgroups in our sample; AD-Memory (n = 41), AD-Executive (n = 117), AD-Language (n = 33), AD-Visuospatial (n = 171). We performed voxel-wise contrasts of GM volumes derived from 3Tesla structural MRI between subgroups and controls (n = 127, age 58 ± 9, 42% male, MMSE 29 ± 1), and observed that differences in regional GM volumes compared to controls closely matched the respective cognitive profiles. Specifically, we detected lower medial temporal lobe GM volumes in AD-Memory, lower fronto-parietal GM volumes in AD-Executive, asymmetric GM volumes in the temporal lobe (left |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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