An improved procedure for the synthesis of glycine and taurine conjugates of bile acids

Autor: K Y Tserng, D L Hachey, P D Klein
Jazyk: angličtina
Rok vydání: 1977
Předmět:
Zdroj: Journal of Lipid Research, Vol 18, Iss 3, Pp 404-407 (1977)
Druh dokumentu: article
ISSN: 0022-2275
DOI: 10.1016/S0022-2275(20)41691-8
Popis: Glycine and taurine conjugates of 5β-cholanic acids have been synthesized using improved procedures based on the peptide coupling reagent, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline. The conjugates are obtained in chromatographically pure form in yields higher than 90%. The use of this procedure in the large scale preparation of cholyl[1,2-13C2]glycine is described.
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