| Autor: |
Edward A Stern |
| Jazyk: |
angličtina |
| Rok vydání: |
2011 |
| Předmět: |
|
| Zdroj: |
Frontiers in Systems Neuroscience, Vol 5 (2011) |
| Druh dokumentu: |
article |
| ISSN: |
1662-5137 |
| DOI: |
10.3389/fnsys.2011.00047 |
| Popis: |
Studies of animal models of Huntington’s Disease (HD) have revealed that neocortical and neostriatal neurons of these animals in vitro exhibit a number of morphological and physiological changes, including increased input resistance and changes in cortical synaptic inputs. We measured the functional effects of polyglutamate accumulation in neocortical neurons in R6/2 mice (8-14 weeks of age) and their age-matched nontransgenic littermates using in vivo intracellular recordings. All neurons showed spontaneous membrane potential fluctuations. The current/voltage and the firing properties of the HD neocortical neurons were significantly altered, especially in the physiologically-relevant current range around and below threshold. As a result, membrane potential transitions from the Down state to Up state were evoked with smaller currents in HD neocortical neurons than in controls. The excitation-to-frequency curves of the HD mice were significantly steeper than those of controls, indicating a smaller input-output dynamic range for these neurons. Increased likelihood of Down to Up state transitions could cause pathological recruitment of corticostriatal assemblies by increasing correlated neuronal activity. We measured coherence of the in vivo intracellular recordings with simultaneously-recorded electrocorticograms. We found that the peak of the coherence at |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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