Inferring and validating mechanistic models of neural microcircuits based on spike-train data

Autor: Josef Ladenbauer, Sam McKenzie, Daniel Fine English, Olivier Hagens, Srdjan Ostojic
Jazyk: angličtina
Rok vydání: 2019
Předmět:
Zdroj: Nature Communications, Vol 10, Iss 1, Pp 1-17 (2019)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-019-12572-0
Popis: It is difficult to fit mechanistic, biophysically constrained circuit models to spike train data from in vivo extracellular recordings. Here the authors present analytical methods that enable efficient parameter estimation for integrate-and-fire circuit models and inference of the underlying connectivity structure in subsampled networks.
Databáze: Directory of Open Access Journals