| Autor: |
Ming-Han Tsai, Hsiang-Ju Shih, Kuan-Wen Su, Sui-Ling Liao, Man-Chin Hua, Tsung-Chieh Yao, Shen-Hao Lai, Kuo-Wei Yeh, Li-Chen Chen, Jing-Long Huang, Chih-Yung Chiu |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Journal of Microbiology, Immunology and Infection, Vol 55, Iss 4, Pp 777-785 (2022) |
| Druh dokumentu: |
article |
| ISSN: |
1684-1182 |
| DOI: |
10.1016/j.jmii.2022.01.006 |
| Popis: |
Background: Airway microbiota may play an important role in regulating the immune response related to allergic respiratory diseases. A molecular-based approach was used to analyze the association between nasopharyngeal microbiota, serum immunoglobin (Ig)E levels, and childhood respiratory allergies. Methods: Nasopharyngeal swabs were collected from children aged 36 months with three phenotypes, including allergic respiratory diseases plus atopy, atopy alone, and healthy controls for microbiome analysis using Illumina-based 16S rRNA gene sequencing. Results: In total, 87 children were enrolled, including 36 with allergic respiratory diseases plus atopy, 21 with atopy alone, and 30 healthy controls. Proteobacteria (45.7%), Firmicutes (29.3%), and Actinobacteria (15.3%) were the most prevalent phyla in the study population. Compared with healthy controls, a lower Chao1 index was found in children with allergies (P |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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