Clinical Evaluation of Subcutaneous Lactate Measurement in Patients after Major Cardiac Surgery

Autor: Martin Ellmerer, Martin Haluzik, Jan Blaha, Jaromir Kremen, Stepan Svacina, Andreas Plasnik, Dimas Ikeoka, Manfred Bodenlenz, Lukas Schaupp, Johannes Plank, Thomas R. Pieber
Jazyk: angličtina
Rok vydání: 2009
Předmět:
Zdroj: International Journal of Endocrinology, Vol 2009 (2009)
Druh dokumentu: article
ISSN: 1687-8337
1687-8345
DOI: 10.1155/2009/390975
Popis: Minimally invasive techniques to access subcutaneous adipose tissue for glucose monitoring are successfully applied in type1 diabetic and critically ill patients. During critical illness, the addition of a lactate sensor might enhance prognosis and early intervention. Our objective was to evaluate SAT as a site for lactate measurement in critically ill patients. In 40 patients after major cardiac surgery, arterial blood and SAT microdialysis samples were taken in hourly intervals. Lactate concentrations from SAT were prospectively calibrated to arterial blood. Analysis was based on comparison of absolute lactate concentrations (arterial blood vs. SAT) and on a 6-hour lactate trend analysis, to test whether changes of arterial lactate can be described by SAT lactate. Correlation between lactate readings from arterial blood vs. SAT was highly significant (r2=0.71, P
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