Quantitative phase-contrast MRI study of cerebrospinal fluid flow: a method for identifying patients with normal-pressure hydrocephalus

Autor: J. Forner Giner, R. Sanz-Requena, N. Flórez, A. Alberich-Bayarri, G. García-Martí, A. Ponz, L. Martí-Bonmatí
Jazyk: angličtina
Rok vydání: 2014
Předmět:
Zdroj: Neurología (English Edition), Vol 29, Iss 2, Pp 68-75 (2014)
Druh dokumentu: article
ISSN: 2173-5808
DOI: 10.1016/j.nrleng.2013.12.006
Popis: Objectives: The aim of this study was to evaluate the use of phase-contrast MR imaging to diagnose normal pressure hydrocephalus (NPH) and differentiate it from other neurological disorders with similar clinical symptoms. Methods: The study included 108 subjects, of whom 61 were healthy controls and 47, patients; in the patient group, 19 had cerebrovascular disease (CVD) and 28 had NPH. All patients underwent a phase-contrast MRI study and several CSF flow and velocity parameters were measured at the aqueduct of Sylvius. Discriminant analyses were performed to evaluate the classification capacity of both individual parameters and the combination of different parameters. Results: Maximum diastolic velocity, mean flow, and stroke volume showed statistically significant differences that could be used to distinguish between NPH and CVD patients (P
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