Implementation of p16/Ki67 dual stain cytology in a Danish routine screening laboratory: Importance of adequate training and experience

Autor:	Anne Hammer, Line W. Gustafson, Pia N. Christensen, Rikke Brøndum, Berit Andersen, Rikke H. Andersen, Mette Tranberg
Jazyk:	angličtina
Rok vydání:	2020
Předmět:	cervical cancer screening cytology dual stain implementation mass screening training Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Cancer Medicine, Vol 9, Iss 21, Pp 8235-8242 (2020)
Druh dokumentu:	article
ISSN:	2045-7634
DOI:	10.1002/cam4.3399
Popis:	Abstract Background Immunocytochemical staining with p16/Ki67 has been suggested as a promising triage biomarker in cervical cancer screening. As dual staining is a subjective method, proper training may be required to ensure safe implementation in routine laboratories and reduce risk of misclassification. We determined concordance between novice evaluators and an expert, stratified by number of slides reviewed at three reading points. Methods The study was conducted at the Department of Pathology, Randers, Denmark. Women were eligible if they were aged ≥45, had been enrolled in one of two ongoing clinical studies, and had a dual stain slide available. Dual staining was performed using the CINtec plus assay. Slides were randomly selected from three reading points at which novice evaluators had reviewed
Databáze:	Directory of Open Access Journals
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