Inactivation of the MSTN gene expression changes the composition and function of the gut microbiome in sheep

Autor: Chenchen Du, Xianhui Zhou, Ke Zhang, Shuhong Huang, Xiaolong Wang, Shiwei Zhou, Yulin Chen
Jazyk: angličtina
Rok vydání: 2022
Předmět:
Zdroj: BMC Microbiology, Vol 22, Iss 1, Pp 1-11 (2022)
Druh dokumentu: article
ISSN: 1471-2180
DOI: 10.1186/s12866-022-02687-8
Popis: Abstract Background Myostatin (MSTN) negatively regulates the muscle growth in animals and MSTN deficient sheep have been widely reported previously. The goal of this study was to explore how MSTN inactivation influences their gut microbiota composition and potential functions. Results We compared the slaughter parameters and meat quality of 3 MSTN-edited male sheep and 3 wild-type male sheep, and analyzed the gut microbiome of the MSTN-edited sheep (8 female and 8 male sheep) and wild-type sheep (8 female and 8 male sheep) through metagenomic sequencing. The results showed that the body weight, carcass weight and eye muscle area of MSTN-edited sheep were significantly higher, but there were no significant differences in the meat quality indexes. At the microbial level, the alpha diversity was significantly higher in the MSTN-edited sheep (P
Databáze: Directory of Open Access Journals
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