Autor: |
Mario Andres Hernandez-Sómerson, Fernando Montoya-Agudelo, Gustavo Huertas-Rodriguez |
Jazyk: |
angličtina |
Rok vydání: |
2024 |
Předmět: |
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Zdroj: |
International Journal of Cardiology. Cardiovascular Risk and Prevention, Vol 22, Iss , Pp 200298- (2024) |
Druh dokumentu: |
article |
ISSN: |
2772-4875 |
DOI: |
10.1016/j.ijcrp.2024.200298 |
Popis: |
Background: The objective of this research is to evaluate the efficacy and safety of drugs in the residual risk in any of its three components: lipid, inflammatory and thrombotic risk. Methods: A systematic review was conducted of randomized clinical trials that included as a primary outcome, at least one of the conditions related to atherosclerotic cardiovascular disease. The databases used were PUBMED/MEDLINE, Scopus and ClinicalTrials.gov. The risk of bias of the studies was assessed using the Risk of Bias 2 tool. Results: and discussion: 18 studies were included in the analysis. Half of the studies had low risk of bias or some concerns. Several drugs were effective in reducing the primary outcome: ethyl eicosapentaenoeic acid (17.2 % E-EPA versus 22 % placebo HR: 0.75; 95 % CI 0.68–0.83; p |
Databáze: |
Directory of Open Access Journals |
Externí odkaz: |
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