| Autor: |
Andreeva-Gateva P., Tchekalarova J., Kamenova K., Strokova-Stoilova M., Chakar S., Hadjiolova R., Angelova V. T., Surcheva Sl. |
| Jazyk: |
angličtina |
| Rok vydání: |
2021 |
| Předmět: |
|
| Zdroj: |
Acta Medica Bulgarica, Vol 48, Iss 1, Pp 25-33 (2021) |
| Druh dokumentu: |
article |
| ISSN: |
0324-1750 |
| DOI: |
10.2478/amb-2021-0004 |
| Popis: |
Aim/objective. When applied in pharmacological doses, the indole derivative melatonin exhibits neuroactive and neuroprotective effects. Indoles and their metabolites, such as kynurenine, are ligands of aryl hydrocarbon receptors (AhR). This study aimed to evaluate the antiepileptic and analgesic activity of melatonin and two synthetic melatonin derivatives. The possible involvement of AhR and kynurenine in their neuropharmacological effects were also tested. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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