microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

Autor: Takahiro Horie, Tetsushi Nakao, Yui Miyasaka, Tomohiro Nishino, Shigenobu Matsumura, Fumiko Nakazeki, Yuya Ide, Masahiro Kimura, Shuhei Tsuji, Randolph Ruiz Rodriguez, Toshimitsu Watanabe, Tomohiro Yamasaki, Sijia Xu, Chiharu Otani, Sawa Miyagawa, Kazuki Matsushita, Naoya Sowa, Aoi Omori, Jin Tanaka, Chika Nishimura, Masataka Nishiga, Yasuhide Kuwabara, Osamu Baba, Shin Watanabe, Hitoo Nishi, Yasuhiro Nakashima, Marina R. Picciotto, Haruhisa Inoue, Dai Watanabe, Kazuhiro Nakamura, Tsutomu Sasaki, Takeshi Kimura, Koh Ono
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nature Communications, Vol 12, Iss 1, Pp 1-17 (2021)
Druh dokumentu: article
ISSN: 2041-1723
DOI: 10.1038/s41467-021-21107-5
Popis: Adaptive thermogenesis is regulated by central neuronal circuits. Here, the authors show that microRNA-33 in the brain contributes to the maintenance of brown adipose tissue thermogenesis and whole-body energy balance via enhanced sympathetic nerve tone, and regulating the expression of GABAa receptor subunits.
Databáze: Directory of Open Access Journals