Coronary Spasm Testing with Acetylcholine: A Powerful Tool for a Personalized Therapy of Coronary Vasomotor Disorders

Autor: Filippo Luca Gurgoglione, Luigi Vignali, Rocco Antonio Montone, Riccardo Rinaldi, Giorgio Benatti, Emilia Solinas, Antonio Maria Leone, Domenico Galante, Gianluca Campo, Simone Biscaglia, Italo Porto, Stefano Benenati, Giampaolo Niccoli
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Life, Vol 14, Iss 3, p 292 (2024)
Druh dokumentu: article
ISSN: 14030292
2075-1729
DOI: 10.3390/life14030292
Popis: Coronary vasomotor disorders (CVD) are characterized by transient hypercontraction of coronary vascular smooth muscle cells, leading to hypercontraction of epicardial and/or microvascular coronary circulation. CVDs play a relevant role in the pathogenesis of ischemia, angina and myocardial infarction with non-obstructive coronary arteries. Invasive provocative testing with intracoronary Acetylcholine (ACh) administration is the gold standard tool for addressing CVD, providing relevant therapeutic and prognostic implications. However, safety concerns preclude the widespread incorporation of the ACh test into clinical practice. The purpose of this review is to shed light on the pathophysiology underlying CVD and on the clinical role of the ACh test, focusing on safety profile and prognostic implications. We will also discuss contemporary evidence on the management of CVD and the role of the ACh test in driving a personalized approach of patients with CVD.
Databáze: Directory of Open Access Journals
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