Increased effort during partial ventilatory support is not associated with lung damage in experimental acute lung injury

Autor:	Dietrich Henzler, Alf Schmidt, Zhaolin Xu, Nada Ismaiel, Haibo Zhang, Arthur S. Slutsky, Paolo Pelosi
Jazyk:	angličtina
Rok vydání:	2019
Předmět:	Acute lung injury ALI Acute respiratory distress syndrome ARDS Ventilator-associated lung injury VALI Medical emergencies. Critical care. Intensive care. First aid RC86-88.9
Zdroj:	Intensive Care Medicine Experimental, Vol 7, Iss 1, Pp 1-13 (2019)
Druh dokumentu:	article
ISSN:	2197-425X
DOI:	10.1186/s40635-019-0272-z
Popis:	Abstract Background An on-going debate exists as to whether partial ventilatory support is lung protective in an acute phase of ARDS. So far, the effects of different respiratory efforts on the development of ventilator-associated lung injury (VALI) have been poorly understood. To test the hypothesis whether respiratory effort itself promotes VALI, acute lung injury (ALI) was induced in 48 Sprague Dawley rats by hydrochloric acid aspiration model. Hemodynamics, gas-exchange, and respiratory mechanics were measured after 4 h of ventilation in pressure control (PC), assist-control (AC), or pressure support with 100% (PS100), 60% (PS60), or 20% (PS20) of the driving pressure during PC. VALI was assessed by histological analysis and biological markers. Results ALI was characterized by a decrease in PaO2/FiO2 from 447 ± 75 to 235 ± 90 mmHg (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8515d5a2e21f48e0a5510d103364b850 Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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