Deworming women of reproductive age during adolescence and pregnancy: what is the impact on morbidity from soil-transmitted helminths infection?

Autor: Carolin Vegvari, Federica Giardina, Sumali Bajaj, Veronica Malizia, Robert J. Hardwick, James E. Truscott, Antonio Montresor, Sake J. de Vlas, Luc E. Coffeng, Roy M. Anderson
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Parasites & Vectors, Vol 14, Iss 1, Pp 1-11 (2021)
Druh dokumentu: article
ISSN: 1756-3305
DOI: 10.1186/s13071-021-04620-w
Popis: Abstract Background Soil-transmitted helminths (STHs) are a major cause of poor health in low- and middle-income countries. In particular, hookworm is known to cause anaemia in children and women of reproductive age (WRA). One goal of the World Health Organization’s (WHO) 2030 roadmap for neglected tropical diseases is to reduce STH-related morbidity in WRA. As a minimal intervention, the WHO recommends deworming adolescent girls annually during human papilloma virus vaccination programmes and WRA during pregnancy and lactation. These routine interventions are low cost and can be implemented even by the most basic health services in endemic countries. In this study we use a cohort model to investigate the potential impact on STH-related morbidity in WRA. Results Annual deworming treatment of adolescent girls reduces the prevalence of moderate- and heavy-intensity infections in this age group by up to 60% in moderate transmission settings and by 12–27% in high transmission settings. Treatment of WRA during pregnancy and lactation on its own has a small (
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