| Autor: |
Rocky An, Virginia Katherine Blackwell, Bijan Harandi, Alicia C. Gibbons, Olivia Siu, Iris Irby, Amy Rees, Nadjet Cornejal, Kristina M. Sattler, Tao Sheng, Nicholas C. Syracuse, David Loftus, Sergio R. Santa Maria, Egle Cekanaviciute, Sigrid S. Reinsch, Hami E. Ray, Amber M. Paul |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
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| Zdroj: |
npj Microgravity, Vol 10, Iss 1, Pp 1-8 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2373-8065 |
| DOI: |
10.1038/s41526-023-00293-0 |
| Popis: |
Abstract Spaceflight and terrestrial spaceflight analogs can alter immune phenotypes. Macrophages are important immune cells that bridge the innate and adaptive immune systems and participate in immunoregulatory processes of homeostasis. Furthermore, macrophages are critically involved in initiating immunity, defending against injury and infection, and are also involved in immune resolution and wound healing. Heterogeneous populations of macrophage-type cells reside in many tissues and cause a variety of tissue-specific effects through direct or indirect interactions with other physiological systems, including the nervous and endocrine systems. It is vital to understand how macrophages respond to the unique environment of space to safeguard crew members with appropriate countermeasures for future missions in low Earth orbit and beyond. This review highlights current literature on macrophage responses to spaceflight and spaceflight analogs. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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Full text from SpringerLink