Intrastriatal CERE-120 (AAV-Neurturin) protects striatal and cortical neurons and delays motor deficits in a transgenic mouse model of Huntington's disease

Autor:	Shilpa Ramaswamy, Jodi L. McBride, Ina Han, Elizabeth M. Berry-Kravis, Lili Zhou, Christopher D. Herzog, Mehdi Gasmi, Raymond T. Bartus, Jeffrey H. Kordower
Jazyk:	angličtina
Rok vydání:	2009
Předmět:	Huntington's disease N171-82Q Neurturin CERE-120 Gene therapy Transgenic mouse model Neurosciences. Biological psychiatry. Neuropsychiatry RC321-571
Zdroj:	Neurobiology of Disease, Vol 34, Iss 1, Pp 40-50 (2009)
Druh dokumentu:	article
ISSN:	1095-953X
DOI:	10.1016/j.nbd.2008.12.005
Popis:	Members of the GDNF family of ligands, including neurturin (NTN), have been implicated as potential therapeutic agents for Huntington's disease (HD). The present study examined the ability of CERE-120 (AAV2-NTN) to provide structural and functional protection in the N171-82Q transgenic HD mouse model. AAV2-NTN therapy attenuated rotorod deficits in this mutant relative to control treated transgenics (p
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/85036ebf5eff4545ae6bd002f2343878 Zobrazit plný text záznamu Full Text from ScienceDirect View record in DOAJ