Antimalarial Inhibitors Targeting Epigenetics or Mitochondria in Plasmodium falciparum: Recent Survey upon Synthesis and Biological Evaluation of Potential Drugs against Malaria

Autor:	Christina L. Koumpoura, Anne Robert, Constantinos M. Athanassopoulos, Michel Baltas
Jazyk:	angličtina
Rok vydání:	2021
Předmět:	malaria epigenetic mitochondria synthesis activities drug candidates Organic chemistry QD241-441
Zdroj:	Molecules, Vol 26, Iss 18, p 5711 (2021)
Druh dokumentu:	article
ISSN:	1420-3049
DOI:	10.3390/molecules26185711
Popis:	Despite many efforts, malaria remains among the most problematic infectious diseases worldwide, mainly due to the development of drug resistance by P. falciparum. Over the past decade, new essential pathways have been emerged to fight against malaria. Among them, epigenetic processes and mitochondrial metabolism appear to be important targets. This review will focus on recent evolutions concerning worldwide efforts to conceive, synthesize and evaluate new drug candidates interfering selectively and efficiently with these two targets and pathways. The focus will be on compounds/scaffolds that possess biological/pharmacophoric properties on DNA methyltransferases and HDAC’s for epigenetics, and on cytochrome bc1 and dihydroorotate dehydrogenase for mitochondrion.
Databáze:	Directory of Open Access Journals
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