Transcriptomic Research in Heart Failure with Preserved Ejection Fraction: Current State and Future Perspectives

Autor: Sebastian Rosch, Karl-Philipp Rommel, Markus Scholz, Holger Thiele, Philipp Lurz
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Cardiac Failure Review, Vol 6, Iss , Pp - (2020)
Druh dokumentu: article
ISSN: 2057-7559
2057-7540
DOI: 10.15420/cfr.2019.19
Popis: Heart failure with preserved ejection fraction (HFpEF) is increasing in incidence and has a higher prevalence compared with heart failure with reduced ejection fraction. So far, no effective treatment of HFpEF is available, due to its complex underlying pathophysiology and clinical heterogeneity. This article aims to provide an overview and a future perspective of transcriptomic biomarker research in HFpEF. Detailed characterisation of the HFpEF phenotype and its underlying molecular pathomechanisms may open new perspectives regarding early diagnosis, improved prognostication, new therapeutic targets and tailored therapies accounting for patient heterogeneity, which may improve quality of life. A combination of cross-sectional and longitudinal study designs with sufficiently large sample sizes are required to support this concept.
Databáze: Directory of Open Access Journals
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