| Autor: |
Deepak Kumar, Rina Ghosh, Bikas C. Pal |
| Jazyk: |
angličtina |
| Rok vydání: |
2013 |
| Předmět: |
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| Zdroj: |
Journal of Functional Foods, Vol 5, Iss 3, Pp 1135-1141 (2013) |
| Druh dokumentu: |
article |
| ISSN: |
1756-4646 |
| DOI: |
10.1016/j.jff.2013.03.010 |
| Popis: |
Potentilla fulgens is used extensively in traditional system of medicine and as a food additive for the treatment of diabetes mellitus and other ailments. The present study was aimed to isolate and identify the constituents with α-glucosidase inhibitory activity. The methanolic extract demonstrated potent inhibitory activity against α-glucosidase. Fractionation and purification by silica gel column chromatography and HPLC led to the isolation of five terpenes, namely, hyptadienic acid, tormentic acid, rosamultic acid, 2α,19α-dihydroxy-3-oxo-12-ursen-28-oic acid β-d-glucopyranoside ester and kajiichigoside F1 for the first time from this plant. Among these hyptadienic acid, which is an A-ring contracted triterpenoid, was found to be the most potent against α-glucosidase. This suggests that the A-ring contracted triterpenes may serve as a class of triterpenes with α-glucosidase inhibitory activity. Also, identification of enzyme inhibitory activity of these constituents explains the traditional use of P. fulgens in the management/treatment of diabetes. Quantitative estimation of the compounds was performed using HPLC and the method was validated. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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