A Case of Nonislet Cell Tumor Hypoglycemia Due to Metastatic Salivary Myoepithelial Carcinoma

Autor: Margaret C. Slack, MD, Samantha Sovich, MD, Chana R. Sachs, MD, Dorothy Martinez, MD, Run Yu, MD
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: AACE Clinical Case Reports, Vol 10, Iss 5, Pp 184-187 (2024)
Druh dokumentu: article
ISSN: 2376-0605
DOI: 10.1016/j.aace.2024.06.002
Popis: Background/Objective: Nonislet cell tumor hypoglycemia (NICTH) is an uncommon cause of hypoglycemia due to a relative surplus of insulin-like growth factor 2 (IGF-2) or its precursor molecule. The diagnosis is confirmed by an elevated ratio of IGF-2 to insulin-like growth factor 1 (IGF-1). Myoepithelial carcinoma (MECA) is a rare and aggressive salivary gland cancer that has not been previously associated with NICTH. Case Report: A 63-year-old female with a past medical history of metastatic salivary MECA, type 2 diabetes mellitus previously on metformin, hypertension, and hypothyroidism presented to her oncologist for chemotherapy and was found to have a serum glucose of 30 mg/dL (reference: 65-99). She was admitted for further diagnostic work-up which revealed an insulin level of
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