Ecological and evolutionary perspectives on tick-borne pathogen co-infections

Autor: Andrea Gomez-Chamorro, Adnan Hodžić, Kayla C. King, Alejandro Cabezas-Cruz
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Current Research in Parasitology and Vector-Borne Diseases, Vol 1, Iss , Pp 100049- (2021)
Druh dokumentu: article
ISSN: 2667-114X
DOI: 10.1016/j.crpvbd.2021.100049
Popis: Tick-borne pathogen co-infections are common in nature. Co-infecting pathogens interact with each other and the tick microbiome, which influences individual pathogen fitness, and ultimately shapes virulence, infectivity, and transmission. In this review, we discuss how tick-borne pathogens are an ideal framework to study the evolutionary dynamics of co-infections. We highlight the importance of inter-species and intra-species interactions in vector-borne pathogen ecology and evolution. We also propose experimental evolution in tick cell lines as a method to directly test the impact of co-infections on pathogen evolution. Experimental evolution can simulate in real-time the long periods of time involved in within-vector pathogen interactions in nature, a major practical obstacle to cracking the influence of co-infections on pathogen evolution and ecology.
Databáze: Directory of Open Access Journals
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