| Autor: |
Minchenko Oleksandr H., Sliusar Myroslava Y., Khita Olena O., Viletska Yuliia M., Luzina Olha Y., Danilovskyi Serhiy V., Minchenko Dmytro O. |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
Endocrine Regulations, Vol 58, Iss 1, Pp 144-152 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
1336-0329 |
| DOI: |
10.2478/enr-2024-0016 |
| Popis: |
Objective. Serine hydroxymethyltransferase (SHMT2) plays a multifunctional role in mitochondria (folate-dependent tRNA methylation, translation, and thymidylate synthesis). The endoplasmic reticulum stress, hypoxia, and glucose and glutamine supply are significant factors of malignant tumor growth including glioblastoma. Previous studies have shown that the knockdown of the endoplasmic reticulum to nucleus signaling 1 (ERN1) pathway of endoplasmic reticulum stress strongly suppressed glioblastoma cell proliferation and modified the sensitivity of these cells to hypoxia and glucose or glutamine deprivations. The present study aimed to investigate the regulation of the SHMT2 gene in U87MG glioblastoma cells by ERN1 knockdown, hypoxia, and glucose or glutamine deprivations with the intent to reveal the role of ERN1 signaling in sensitivity of this gene expression to hypoxia and nutrient supply. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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