| Autor: |
Carolline Araujo-Mariz, Maria de Fátima P. Militão de Albuquerque, Edmundo P. Lopes, Ricardo A.A. Ximenes, Heloísa R. Lacerda, Demócrito B. Miranda-Filho, Brena B. Lustosa-Martins, André Filipe P. Pastor, Bartolomeu Acioli-Santos |
| Jazyk: |
angličtina |
| Rok vydání: |
2020 |
| Předmět: |
|
| Zdroj: |
Annals of Hepatology, Vol 19, Iss 2, Pp 153-160 (2020) |
| Druh dokumentu: |
article |
| ISSN: |
1665-2681 |
| DOI: |
10.1016/j.aohep.2019.09.008 |
| Popis: |
Introduction and objective: Hepatotoxicity during tuberculosis (TB) treatment is frequent and may be related to the Arylamine N-Acetyltransferase (NAT2) acetylator profile, in which allele frequencies differ according to the population. The aim of this study was to investigate functional polymorphisms in NAT2 associated with the development of hepatotoxicity after initiating treatment for TB in people living with HIV/AIDS (PLWHA) in Pernambuco, Northeast Brazil. Material and methods: This was a prospective cohort study that investigated seven single nucleotide polymorphisms located in the NAT2 coding region in 173 PLWHA undergoing TB treatment. Hepatotoxicity was defined as elevated aminotransferase levels and identified as being three times higher than it was before initiating TB treatment, with associated symptoms of hepatitis. A further 80 healthy subjects, without HIV infection or TB were used as a control group. All individuals were genotyped by direct sequencing. Results: The NAT2*13A and NAT2*6B variant alleles were significantly associated with the development of hepatotoxicity during TB treatment in PLWHA (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
|
