Transcatheter Aortic Valve Replacement in Patients With Pure Native Aortic Regurgitation: Results From a Multicenter Registry Study

Autor: Xiaofei Gao, Juan Zhang, Xiangquan Kong, Jing Chen, Xiang Chen, Longyan Zhang, Xinyong Cai, Jiancheng Zhu, Nailiang Tian, Zhen Ge, Bin Wang, Qing Zhou, Xi Su, Lang Hong, Yan Wang, Hong Jiang, Junjie Zhang, Shaoliang Chen
Jazyk: angličtina
Rok vydání: 2024
Předmět:
Zdroj: Cardiology Discovery, Vol 4, Iss 2, Pp 134-141 (2024)
Druh dokumentu: article
ISSN: 2096-952X
2693-8499
00000000
DOI: 10.1097/CD9.0000000000000101
Popis: Objective:. Patients with untreated severe aortic regurgitation (AR) have a high risk of mortality. Transfemoral transcatheter aortic valve replacement (TF-TAVR) is a treatment option for AR; however, the safety and efficacy of this technique have not been sufficiently established. This study aimed to evaluate the clinical and anatomical variables correlating with device success of TF-TAVR using a self-expanding valve system for pure AR. Methods:. Patients with pure native severe AR who underwent TF-TAVR using a self-expanding valve system were registered at 5 Chinese centers. The primary endpoint was device success at 1 month after TAVR. The secondary endpoint was the composite of major adverse cardiovascular events (MACE) at 6 months, including all-cause death, ischemic stroke, emergency conversion to cardiac surgery, and permanent pacemaker implantation. Echocardiography was used to analyze the left ventricular function before the TAVR procedure and during follow-up. Multivariable logistic regression and Cox regression analyses were performed to find relevant independent risk factors. Results:. Between September 2019 and February 2022, 79 patients with AR were enrolled in the study. At 1 month, device success was achieved in 60 (75.9%) patients. By 6 months, 29 (36.7%) patients had MACE. Echocardiography revealed improved left ventricular function after TAVR. Multivariate regression analysis demonstrated that the Society of Thoracic Surgeons risk score (odds ratio 0.760, 95% confidence interval (CI): 0.584–0.989; P = 0.041) and annulus perimeter (odds ratio 0.888, 95% CI: 0.796–0.992; P = 0.035) were 2 predictors of device success. Moreover, annulus perimeter (
Databáze: Directory of Open Access Journals
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