| Autor: |
Karissa Aldrete, MD, Leena Shahla, MD |
| Jazyk: |
angličtina |
| Rok vydání: |
2024 |
| Předmět: |
|
| Zdroj: |
AACE Clinical Case Reports, Vol 10, Iss 6, Pp 232-235 (2024) |
| Druh dokumentu: |
article |
| ISSN: |
2376-0605 |
| DOI: |
10.1016/j.aace.2024.08.002 |
| Popis: |
Background/Objective: Pulmonary carcinoid tumors are a rare cause of Cushing’s syndrome and usually present with an indolent course. Here, we present a case of rapid onset and severe Cushing’s syndrome due to a typical pulmonary carcinoid tumor. Case Report: A 32-year-old woman developed diabetes, hypertension, and weight gain of 50 pounds over 3 months. Laboratory evaluation was significant for elevated cortisol and adrenocorticotropic hormone levels and levels were nonsuppressible on low and high-dose dexamethasone suppression tests. Chest computed tomography revealed a pulmonary nodule and biopsy showed a typical carcinoid tumor. She was treated with steroidogenesis inhibitors with a plan for surgical excision but developed worsening complications of hypercortisolemia. She eventually underwent cryoablation of the tumor, but unfortunately passed away just 6 months after her initial presentation. Discussion: Cushing’s syndrome in typical pulmonary carcinoid tumors is rarely seen and usually presents with mild hypercortisolism similar to Cushing’s disease. Severe hypercortisolemia from typical pulmonary carcinoid tumors can represent a more aggressive pathology or metastatic disease. Severe Cushing’s syndrome is associated with significant morbidity and mortality and requires rapid tumor localization as surgical resection can be curative. Conclusion: This case highlights a rare presentation of severe Cushing’s syndrome due to a typical pulmonary carcinoid. |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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