Fulminant hepatic failure after repeated exposure to isoflurane

Autor: Halemani R Kusuma, Neelam K Venkataramana, Shailesh AV Rao, Arun L Naik, D S Gangadhara, Keshavan H Venkatesh
Jazyk: angličtina
Rok vydání: 2011
Předmět:
Zdroj: Indian Journal of Anaesthesia, Vol 55, Iss 3, Pp 290-292 (2011)
Druh dokumentu: article
ISSN: 0019-5049
DOI: 10.4103/0019-5049.82696
Popis: Inhalational agents are used routinely for maintenance of anaesthesia. Post anaesthesia hepatic failure has been documented following exposure to halothane. However, there are very few reports of such complications following isoflurane anaesthesia. A 6-year-old child developed fulminant hepatic failure 2 days following craniotomy under general anaesthesia. There was no evidence of viral, autoimmune, or metabolic causes of hepatitis. No other medications known to cause hepatitis, except low dose paracetamol, were administered. The clinical and histological picture of our case is similar to that of halothane hepatitis, which has a significant mortality rate. We report this as a possible fulminant hepatic failure resulting from exposure to isoflurane anaesthesia.
Databáze: Directory of Open Access Journals