STUDY OF DOSE-DEPENDENT EFFECT OF 2-ETHYL-6-METHYL-3 HYDROXYPYRIDINE SUCCINATE ON THE CONTRACTILE FUNCTION OF ISOLATED RAT HEART
| Autor: | Oleg Kesarev, Lyudmila Danilenko, Mikhail Pokrovskii, Alena Alena, Anatolii Khavanskii |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | Research Results in Pharmacology, Vol 3, Iss 1, Pp 3-9 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2500-235X 2658-381X |
| DOI: | 10.18413/2500-235X-2017-3-1-3-9 |
| Popis: | In experiments on the isolated rat heart there were studied the effects of different doses (21.43 mg/kg/day and 85.72 mg/kg/day) 2-ethyl-6-methyl-3 hydroxypyridine succinate ("EkoPharmInvest", Russia), on the contractile function of isolated hearts subjected to prior doxorubicin model (20 mg/kg, intraperitoneal) of pathology. The dynamic of the power mechanisms of ion transport was evaluated by imposing high heart rate (480 BPM) and increase concentration of Са2+ to 5 mmol in perfusate. The results indicate that Mexicor at the dose of 21.43 mg/kg/day does not provide a cardioprotective effect in this model of pathology. Mexicor has the cardioprotective effect at the dose of 85.72 mg/kg/day in relation to the isolated heart, that is resulted in the recovery of the contractile function of the heart and reducing the "diastole defect" (SТТI). |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
|