Effect of multidrug solution for the treatment of chemotherapy-induced oral mucositis in vivo

Autor: Rebecca Rhuanny Tolentino Limeira, Isabella Lima Arrais Ribeiro, Paulo Rogério Ferreti Bonan, Danielle da Nóbrega Alves, Elba dos Santos Ferreira, Tereza Karla Vieira Lopes da Costa, Cassiano Francisco Weege Nonaka, Ana Claúdia Dantas de Medeiros, Frederico Barbosa de Sousa, Ana Maria Gondim Valença, Ricardo Dias de Castro
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Saudi Dental Journal, Vol 35, Iss 4, Pp 378-385 (2023)
Druh dokumentu: article
ISSN: 1013-9052
DOI: 10.1016/j.sdentj.2023.03.014
Popis: Objective: Evaluate the effect of a multidrug solution, adopted by a referral hospital for cancer to control and treat chemotherapy-induced oral mucositis in rats. Methods: Oral mucositis (OM) was induced by 5-Fluorouracil (5-FU), and the animals were treated with saline (n = 8, G1), 0.12% chlorhexidine (n = 8, G2); and multidrug solution (n = 8, G3). The animals were submitted to clinical and histological analysis of the lesion using mucosal fragments. The animals' food consumption during treatment was also evaluated. Results: Clinical improvement (p
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