Low plasma vitamin D as a predictor of uterine fibroids in a nigerian population

Autor: Karima Abubakar Tunau, Jamila Abubakar Garba, Abubakar Abubakar Panti, Constance Egondu Shehu, Aisha Nana Adamu, Muhammad Bashir AbdulRahman, Mohammad Kaoje Ahmad
Jazyk: angličtina
Rok vydání: 2021
Předmět:
Zdroj: Nigerian Postgraduate Medical Journal, Vol 28, Iss 3, Pp 181-186 (2021)
Druh dokumentu: article
ISSN: 1117-1936
2468-6875
DOI: 10.4103/npmj.npmj_495_21
Popis: Background: Uterine fibroid is the most common benign tumour of the uterus and the exact cause is unknown. Vitamin D has been found to inhibit cell proliferation and enhance apoptosis in vitro. Aim: The aim of this study is to compare the plasma level of Vitamin D among women with uterine fibroids and those without uterine fibroids. Materials and Methods: This was an analytical cross-sectional study conducted among women with uterine fibroids and those without uterine fibroids. An interviewer-administered questionnaire was used to obtain relevant information. Five millilitres of venous blood was obtained for plasma Vitamin D assay. Data analysis was performed using the SPSS version 22. Level of significance was set at P < 0.05. Results: There were 100 participants recruited for the study. The mean age of the participants with uterine fibroid was 35.06 ± 6.6 years and that of controls was 33.28 ± 7 years. The mean plasma level of Vitamin D for all the participants was 12.47 ± 7.53 ng/ml. The mean plasma level of Vitamin D in those with uterine fibroids was significantly lower than in those without uterine fibroid (10.16 ± 7.78 vs. 14.35 ± 6.8; t = 2.517, P = 0.014). It also shows that 1 unit increase in Vitamin D level will reduce the risk of developing uterine fibroids by 8% (odds ratio = 0.92, 95% confidence interval = 0.86–0.99). Conclusion: The predictors of uterine fibroids were fewer hours spent outdoors, middle social class and low Vitamin D levels.
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