Progressive Multifocal Leukoencephalopathy Unmasked by Teclistamab in a Refractory Multiple Myeloma Patient

Autor:	Panos Arvanitis, Dimitrios Farmakiotis, Ari Pelcovits
Jazyk:	angličtina
Rok vydání:	2024
Předmět:	multiple myeloma Progressive Multifocal Leukoencephalopathy teclistamab bispecific antibodies Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Zdroj:	Current Oncology, Vol 31, Iss 5, Pp 2670-2678 (2024)
Druh dokumentu:	article
ISSN:	1718-7729 1198-0052
DOI:	10.3390/curroncol31050202
Popis:	This case report describes the development of Progressive Multifocal Leukoencephalopathy (PML) in a 72-year-old male with relapsed/refractory multiple myeloma (RRMM), following a single dose of teclistamab amidst a COVID-19 infection. Shortly after starting teclistamab treatment, the patient developed symptoms, including fever, altered mental status, and right-sided paresis. A diagnosis of PML was confirmed through the detection of JC virus PCR in the cerebrospinal fluid. Our report emphasizes the occurrence of PML after only one dose of teclistamab and highlights teclistamab’s potential for severe infectious complications, despite its promise in treating RRMM.
Databáze:	Directory of Open Access Journals
Externí odkaz:	https://doaj.org/article/8452a26ee01c4268a7790ceed62c1aab Zobrazit plný text záznamu View record in DOAJ Plný text ve formátu PDF Plný text ve formátu HTML
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