Elevated Serum Ceruloplasmin Levels Are Associated with Higher Impulsivity in People with Parkinson’s Disease

Autor: Megan C. Bakeberg, Maddeson Riley, Michelle Byrnes, Alexa Jefferson, Souyma Ghosh, Malcom K. Horne, Sarah McGregor, Rick Stell, Sue Walters, Tess Evans, Katherine Roberts, Frank L. Mastaglia, Ryan S. Anderton
Jazyk: angličtina
Rok vydání: 2020
Předmět:
Zdroj: Parkinson's Disease, Vol 2020 (2020)
Druh dokumentu: article
ISSN: 2090-8083
2042-0080
DOI: 10.1155/2020/8296203
Popis: Background. Heightened impulsivity has been reported in a subset of people with Parkinson’s disease (PwP) and is considered a risk factor for the development of impulse control disorders (ICDs). However, at present, there are no recognised biochemical markers of heightened impulsivity. Objectives. To determine if ceruloplasmin, a serum marker involved in the regulation of iron and copper homeostasis, is associated with trait impulsivity in PwP. Methods. The study measured serum ceruloplasmin and impulsivity using the Barratt Impulsiveness Scale (BIS-11) in an Australian cohort of 214 PwP. Multivariate general linear models (GLMs) were used to identify whether higher serum ceruloplasmin levels (>75th percentile) were significantly predictive of BIS-11 scores. Results. Serum ceruloplasmin was higher in females with PD (p
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