Interleukin-28B rs12979860 C/T Polymorphism and Acute Cellular Rejection after Liver Transplantation
| Autor: | H Fereidooni, N Azarpira, R Yaghobi, A Vahdati, SA Malek-Hosseini |
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| Jazyk: | angličtina |
| Rok vydání: | 2017 |
| Předmět: | |
| Zdroj: | International Journal of Organ Transplantation Medicine, Vol 8, Iss 1 (2017) |
| Druh dokumentu: | article |
| ISSN: | 2008-6482 2008-6490 |
| Popis: | Background: Interleukin-28 (IL-28B) rs12979860 C/T polymorphism is a known predictor of sustained virological response after antiviral treatment in hepatitis C. IL-28B affects the innate immune system as well as intrahepatic expression level of interferon-stimulated genes. Objective: To investigate the effect of recipient IL-28B polymorphism on occurrence of acute rejection after liver transplantation. Methods: 140 liver allograft recipients were selected. Acute rejection episodes were recorded in 39 patients (AR group); the remaining had normal graft function (non-AR group). 70 normal subjects were also studied as the control group. The IL-28B rs12979860 was genotyped through PCR-RFLP method. Results: No significant difference was found between AR and non-AR groups in terms of genotype and allele frequency. However, the CC genotype was significantly (p |
| Databáze: | Directory of Open Access Journals |
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