Assessment of Pertussis Vaccine Protective Effectiveness in Children in the Amhara Regional State, Ethiopia
| Autor: | Solomon Taye, Belay Tessema, Baye Gelaw, Feleke Moges |
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| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: | |
| Zdroj: | International Journal of Microbiology, Vol 2020 (2020) |
| Druh dokumentu: | article |
| ISSN: | 1687-918X 1687-9198 |
| DOI: | 10.1155/2020/8845835 |
| Popis: | Background. Bordetella pertussis is a human pathogen which causes pertussis, or whooping cough. The diphtheria-tetanus-pertussis immunization has significantly reduced the morbidity and mortality of pertussis globally. However, higher prevalence and resurgence of pertussis cases among both vaccinated and unvaccinated people has raised questions on the effectiveness of pertussis vaccine over time. Therefore, the objective of this study was to assess the protective effectiveness of pertussis vaccine in the Amhara Regional State, Ethiopia. Methods. A nested matched case-control study design approach was used with vaccinated individuals as cases and unvaccinated individuals as controls. The study was conducted from July 2018 to February 2019. Real-time (RT-) PCR assay was done to ascertain the presence of pertussis among clinically suspected patients. Bivariable and multivariable logistic regression analyses were computed to estimate the crude and adjusted odds ratios (ORs), respectively. Vaccine effectiveness was calculated as (1 − OR) × 100. Adjusted OR with 95% CI and a P value |
| Databáze: | Directory of Open Access Journals |
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