ANTIFOLATES FOR ANTICANCER CHEMOTHERAPY. PART IІ
| Autor: | V. A. Bacherikov |
|---|---|
| Jazyk: | English<br />Russian<br />Ukrainian |
| Rok vydání: | 2015 |
| Předmět: | |
| Zdroj: | Vìsnik Odesʹkogo Nacìonalʹnogo Unìversitetu: Hìmìâ, Vol 18, Iss 4(48), Pp 26-33 (2015) |
| Druh dokumentu: | article |
| ISSN: | 2304-0947 2414-5963 |
| DOI: | 10.18524/2304-0947.2013.4(48).37019 |
| Popis: | In the review the structure of the basic antifolate antagonists, their intracellular enzyme tar-gets, and their mechanisms of antitumor activity were considered. Folate antimetabolites, which were discovered in the last decade and trends in finding powerful inhibitors of folic acid metabolic pathways, were discussed in details. The advantages and limitations of antifolates that can be used for the design of new drugs for antitumor chemotherapy were considered. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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