Die Entwicklung eines neuen, umweltgerechten Produktions-prozesses f?r Terbinafin
| Autor: | Ulrich Beutler, Jan Mazacek, Gerhard Penn, Berthold Schenkel Und Daniel Wasmuth |
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| Jazyk: | German<br />English<br />French |
| Rok vydání: | 1996 |
| Předmět: | |
| Zdroj: | CHIMIA, Vol 50, Iss 4 (1996) |
| Druh dokumentu: | article |
| ISSN: | 0009-4293 2673-2424 |
| Popis: | An efficient process for the production of terbinafine is described. Starting from (E)-I,3-dichloropropene, neohexene, and N-methyl-( I-naphthylmethyl)amine and using a palladium-catalyzed coupling methodology, terbinafine is produced exclusively as (E)-isomer in a convergent manner. The new process avoids the very toxic and nasty starting materials acrolein and phosphorus pentachloride used in the old process. |
| Databáze: | Directory of Open Access Journals |
| Externí odkaz: |
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