Assessment of N-acetylcysteine use for acetaminophen overdose in the emergency department of a community teaching hospital: A pilot study

Autor: Yasser A Alaska, Sultan M Alghadeer, Abdulaziz A Alrabiah, Abdulaziz Harb, Bana Almadi
Jazyk: angličtina
Rok vydání: 2023
Předmět:
Zdroj: Saudi Journal of Anaesthesia, Vol 17, Iss 2, Pp 168-173 (2023)
Druh dokumentu: article
ISSN: 1658-354X
DOI: 10.4103/sja.sja_707_22
Popis: Introduction: N-acetylcysteine (NAC) is the first-line treatment for acetaminophen (APAP) overdose. However, using NAC inappropriately is associated with an increased risk of adverse effects as well as a substantial increase in hospitalization and healthcare costs. This study aims to assess NAC utilization for acute APAP overdose in the emergency department of a community teaching hospital in Saudi Arabia. Methods: A retrospective chart review in which the patients initiated on an NAC secondary to acute APAP overdose at KSUMC during the period of June 2015 till November 2018 were included and assessed based on developed validated evident-based protocol for administering NAC for acute APAP ingestion. Results: A total of 29 patients received NAC treatment for acute APAP overdose; 15 of which were adults, and 14 were pediatrics. Appropriate prescribing of NAC was observed in 14 (48.28%) patients, whereas NAC was inappropriately indicated for 15 (51.72%) patients; 9 of them were adults and 6 patients were pediatric. APAP-Ingestion
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