Hormone-dependent abnormality of the female sexual sphere during monotherapy with valproate, carbamazepine, and lamotrigine
| Autor: | P. N. Vlasov, O. F. Serova, D. V. Dranko, N. V. Filatova, Z. S. Shakhabasova |
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| Jazyk: | ruština |
| Rok vydání: | 2014 |
| Předmět: | |
| Zdroj: | Неврология, нейропсихиатрия, психосоматика, Vol 4, Iss 1S, Pp 34-38 (2014) |
| Druh dokumentu: | article |
| ISSN: | 2074-2711 2310-1342 |
| DOI: | 10.14412/2074-2711-2012-2496 |
| Popis: | Hormonal function of the ovary was analyzed in 95 childbearing-age (18—30-year-old) epileptic patients receiving monotherapy with antiepileptic drugs (AEDs) for at least a year. Of them, 40, 40, and 15 patients had monotherapy with valproic acid, carbamazepine, or lamotrigine, respectively. Fifty-two (54.7%) patients with epilepsy were observed to have ovarian hormonal dysfunctions characterized by lower progesterone levels and higher luteinizing hormone and testosterone concentrations in both the follicular and luteinic phase of a menstrual cycle. The magnitude of hormonal changes depended on the specific features of epilepsy: duration, form, site of an epileptogenic focus. The use of various AEDs had an insignificant impact on the rate and pattern of hormonal abnormalities. |
| Databáze: | Directory of Open Access Journals |
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