| Autor: |
Sunday Aderemi Adelakun, Babatunde Ogunlade, Obinna Peter Fidelis, Olusegun Dare Omotoso |
| Jazyk: |
angličtina |
| Rok vydání: |
2022 |
| Předmět: |
|
| Zdroj: |
Endocrine and Metabolic Science, Vol 6, Iss , Pp 100116- (2022) |
| Druh dokumentu: |
article |
| ISSN: |
2666-3961 |
| DOI: |
10.1016/j.endmts.2021.100116 |
| Popis: |
Zinc (Zn) has proven to play a key role in spermatogenesis. The present study focused on the nutritional supplementation of Zn against cisplatin (CP)-induced spermatogonial and testicular dysfunctions.Thirty-two (32) mature male Sprague Dawley rats were randomized into four groups of eight (n = 8) rats each – Control group (received 2 ml of normal saline); Zn group (received 1 mg/kg body weight (bwt) of Zn sulfate); Cisplatin group treated intraperitoneally with a single dose (10 mg/kg bwt) of CP; and CP + Zn group, after induction of testicular toxicity, were treated (orally) with 1 mg/kg bwt of Zn sulfate. The procedure lasted for 8 weeks. Parameters tested include testicular histology, sperm parameters, testosterone (TT), follicle-stimulating hormone (FSH) and luteinizing hormone (LH), catalase (CAT), superoxide dismutase (SOD), peroxidase (POD), glutathione reductase (GR), thiobarbituric acid reactive substances (TBARS).Cisplatin significantly decreases (p |
| Databáze: |
Directory of Open Access Journals |
| Externí odkaz: |
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